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anti-BAG-1L (human), Rabbit Monoclonal (RM310)
品牌： Adipogen
产品货号： REV-31-1196-00-R100
规格： 100 µl

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-BAG-1L (human), Rabbit Monoclonal (RM310)
  • 别名:
    Bcl-2-associated Athanogene 1; BAG Family Molecular Chaperone Regulator 1
  • 产品描述:
    BAG-1L belongs to a family of evolutionary conserved proteins, containing an approximately 110 amino acid sequence termed the BAG domain that defines the protein family. BAG1 was identified in a screen of interacting proteins of the anti-apoptotic protein BCL2. BAG1 shares no significant homology with BCL2 or other BCL2 family proteins, which can form homo- and heterodimers. However, coexpression of BAG1 and BCL2 provided markedly increased protection from cell death induced by several stimuli. BAG1 itself is made up of different isoforms translated from a single mRNA by alternative translational initiation, resulting in similar carboxy-terminal sequences but different N-terminal sequences. In humans, there are four BAG1 isoforms (BAG1L, 1M, 1 and 1S). The multiple protein isoforms interact with diverse partners, including chaperones Hsc70/Hsp70, Ser/Thr kinase Raf-1 and Bcl-2, to promote cancer cell survival. The BAG-1L isoform specifically binds to and increases the transcriptional activity of oestrogen receptor in cells, and in some, but not all studies, BAG-1 expression is predictive of clinical outcome in breast cancer.
  • 反应种属:
  • 宿主来源:
    Rabbit
  • 实验应用:
    ICC, IHC, WB
  • 靶标/特异性:
  • 同种型:
    Rabbit IgG
  • 推荐稀释度:
  • 免疫原:
    A peptide corresponding to residues near the N-terminus of human BAG-1L.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    RM310
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
  • 产品特点:
  • 纯度:
    Protein A purified.
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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