anti-Surfactant protein A (human), Rabbit Monoclonal (RM334) - 深圳欣博盛生物科技有限公司

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anti-Surfactant protein A (human), Rabbit Monoclonal (RM334)

品牌： Adipogen

产品货号： REV-31-1221-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-Surfactant protein A (human), Rabbit Monoclonal (RM334)
别名:

SP-A; PSPA; Alveolar Proteinosis Protein
产品描述:

Surfactant protein A (SP-A) is an abundant, phospholipid-associated protein in pulmonary surfactant. SP-A is expressed primarily by type II and bronchiolar cells in the respiratory epithelium. In the alveolus, SP-A forms large oligomers and is closely associated with tubular myelin, the major extracellular form of surfactant. SP-A contains a 10-kDa collagen-like amino-terminal domain and a globular carboxyl-terminal domain with structural homology to SP-D, mannose binding protein, Clq, and other members of the collectin family of mammalian lectins. Together with SP-D, SP-A plays an important role in pulmonary innate immunity by recognizing canonical patterns on microbial surfaces. These host defense proteins protect the lung from infection by recognizing the carbohydrate and/or lipid component on pathogens, including bacteria, virus and fungi, and by helping to initiate various clearance mechanisms. It was shown that SP-A activates alveolar macrophage metabolism, and enhances the uptake of bacterial pathogens by both macrophages and monocytes. In addition, SP-A has been shown to serve as a hormone in parturition through its ability to modulate proinflammatory cytokine production, as well as in several other functions which include enhancing phospholipid uptake, inhibiting surfactant secretion by isolated type II epithelial cells, contributing to tubular myelin formation, enhancing surfactant spreading, stabilizing phospholipid mixtures and conferring resistance to protein mediated inactivation of surfactant. SP-A polymorphisms play a role in respiratory distress syndrome, allergic bronchopulmonary aspergillosis and idiopathic pulmonary fibrosis. The levels of SP-A are decreased in the lungs of patients with cystic fibrosis, respiratory distress syndrome and further chronic lung diseases. The interaction of SP-A with type II cells is a receptor-mediated process.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the C-terminus of human Surfactant protein A (SP-A).
免疫原种属:
克隆性:
克隆号:

RM334
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
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检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
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