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anti-COX-2 (human), Rabbit Monoclonal (RM348)
品牌： Adipogen
产品货号： REV-31-1234-00-R100
规格： 100 µl

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-COX-2 (human), Rabbit Monoclonal (RM348)
  • 别名:
    Cyclooxygenase-2; Prostaglandin G/H synthase 2; PGHS-2
  • 产品描述:
    COX-2 converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis, including production of inflammatory prostaglandins. The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). COX-2 is constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and is up-regulated under pathological conditions, such as in cancer and inflammation. Up-regulation of COX2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, COX-2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. COX-2 is naturally inhibited by calcitriol (the active form of Vitamin D). COX-2 is a target of NSAID such as aspirin, which can reduce pain and swelling from inflammation driven by COX-2.
  • 反应种属:
  • 宿主来源:
    Rabbit
  • 实验应用:
    IHC, WB
  • 靶标/特异性:
  • 同种型:
    Rabbit IgG
  • 推荐稀释度:
  • 免疫原:
    A peptide corresponding to the C-terminus of human COX-2.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    RM348
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
  • 产品特点:
  • 纯度:
    Protein A purified.
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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