anti-CD117 (human), Rabbit Monoclonal (RM359) - 深圳欣博盛生物科技有限公司

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anti-CD117 (human), Rabbit Monoclonal (RM359)

品牌： Adipogen

产品货号： REV-31-1245-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-CD117 (human), Rabbit Monoclonal (RM359)
别名:

Mast/stem Cell Growth Factor Receptor Kit ; SCFR; c-Kit; Piebald Trait Protein; p145 c-kit
产品描述:

CD117 (c-Kit;; Stem cell growth factor receptor; SCFR) is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Overexpression or mutations of this protein can lead to cancer. Upon binding of its ligand stem cell factor (SCF), CD117 dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/CD117 can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. Signaling through CD117 plays a role in cell survival, proliferation, and differentiation. CD117 receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis. Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism. Antibodies to CD117 are widely used in immunohistochemistry to help distinguish particular types of tumour in histological tissue sections.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the C-terminus of human CD117/c-Kit.
免疫原种属:
克隆性:
克隆号:

RM359
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
来源:
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Accession #:
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PubChem CID: