anti-p63 (human), Rabbit Monoclonal (RM383) - 深圳欣博盛生物科技有限公司

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anti-p63 (human), Rabbit Monoclonal (RM383)

品牌： Adipogen

产品货号： REV-31-1269-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-p63 (human), Rabbit Monoclonal (RM383)
别名:

Tumor Protein 63
产品描述:

p63 (TP63; Tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. p63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. p63 plays a role in the regulation of epithelial morphogenesis. p63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia and orofacial cleft. p63 immunostaining has utility for head and neck squamous cell carcinomas, differentiating prostatic adenocarcinoma and benign prostatic tissue. p63 is also helpful in distinguishing poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma. p63 should be strongly stained in poorly differentiated squamous cell, but negative in small cell or adenocarcinoma.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the area surrounding the C-terminus of human p63 (Tumor protein 63).
免疫原种属:
克隆性:
克隆号:

RM383
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
来源:
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