anti-CD71 (human), Rabbit Monoclonal (RM384) - 深圳欣博盛生物科技有限公司

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anti-CD71 (human), Rabbit Monoclonal (RM384)

品牌： Adipogen

产品货号： REV-31-1270-00-R100

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

anti-CD71 (human), Rabbit Monoclonal (RM384)
别名:

Transferrin Receptor Protein 1; T9; p90
产品描述:

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Two types of Transferrin receptors (TfRs) are known, TfR1 (CD71) and TfR2. The latter molecule has only recently been identified and its function remains unclear. In contrast, the role of TfR1 in binding transferrin and delivering Fe to cells is well known. TfR1 exists as an integral membrane homodimer that binds one transferrin molecule per monomer. Binding of transferrin to the TfR1 leads to receptor-mediated endocytosis and the endosome is the site where Fe is released from transferrin. Furthermore, acidification of the endosome by membrane bound proton pumps and the reduction of Fe(III) to Fe(II) are also involved in release and transport of this metal ion into the cell. Once released from transferrin, Fe then passes through the endosomal membrane via the divalent metal transporter 1. The uptake of Fe from transferrin is controlled by TfR1 expression that is modulated by intracellular Fe levels via iron-regulatory proteins. Transferrin receptor 1 is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR1) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. TfR1 as a potential new target in cases of human leukemia and lymphoma.
反应种属:
宿主来源:

Rabbit
实验应用:

IHC, WB
靶标/特异性:
同种型:

Rabbit IgG
推荐稀释度:
免疫原:

A peptide corresponding to the internal region of human CD71.
免疫原种属:
克隆性:
克隆号:

RM384
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
产品特点:
纯度:

Protein A purified.
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
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PubChem CID: