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产品名称:
LAMP1 Antibody: ATTO 488
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别名:
CD107 Antibody, CD107a Antibody, LAMPA Antibody, LGP120 Antibody, IgpA Antibody, Lysosome-associated membrane glycoprotein 1 Antibody, CD107 antigen-like family member A Antibody, 120 kDa lysosomal membrane glycoprotein Antibody, Lamp-1 Antibody
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产品描述:
Mouse Anti-Rat LAMP1 Monoclonal IgG1
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反应种属:
Human | Mouse | Rat | Hamster
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宿主来源:
Mouse
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实验应用:
WB | ICC/IF | IP
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靶标/特异性:
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同种型:
IgG1
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推荐稀释度:
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免疫原:
Rat liver lysosomal membrane preparations
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免疫原种属:
Rat
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克隆性:
Monoclonal
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克隆号:
Ly1C6
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纯化方式:
Protein G Purified
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偶联:
ATTO 488
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产品浓度:
1 mg/ml
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表达系统:
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阳性对照:
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保存温度:
Conjugated antibodies should be stored according to the product label
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运输温度:
Blue Ice or 4ºC
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细胞定位:
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预期分子量:
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产品形式:
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存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl¬terminal tyrosine ba based motif (YXXI) (1). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome (3).
This stimulation has also been shown to have an associated release of histamine, leukotriene C (4) and prostaglandin D (2), which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells (1). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (4).
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样本类型:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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