Hyperoxidized Peroxiredoxin-3 Polyclonal Antibody - 深圳欣博盛生物科技有限公司

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Hyperoxidized Peroxiredoxin-3 Polyclonal Antibody

品牌： Cayman

产品货号： 39806

规格： 100 µg

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折后价：

数量： - +

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产品名称:

Hyperoxidized Peroxiredoxin-3 Polyclonal Antibody
别名:

Antioxidant Protein 1|AOP-1|MER5 Homolog|Mitochondrial Thioredoxin-dependent Peroxide Reductase|Peroxiredoxin III|PRDX3|Prx3
产品描述:

Peroxiredoxin-3 (Prx3) is a typical 2-Cys-containing Prx that is involved in the maintenance of cellular thiol redox homeostasis.{65926} It exists as a homodimer when oxidized and is composed of an N-terminal mitochondrial targeting sequence and a catalytic domain that contains peroxidatic and resolving cysteines (Cp and Cr, respectively).{65926,65927} Reduced Prx3 exists as a monomer and hyperoxidized Prx3 is capable of forming dodecamers.{65927} Prx3 is ubiquitously expressed and localizes to the mitochondrial matrix.{65926,65928} During the catalytic cycle, hydrogen peroxide oxidizes Cp to form a sulfenic acid intermediate (C-SOH), which reacts with the Cr of the opposite subunit to form a disulfide bond that is subsequently restored to a reduced state by thioredoxin 2 (Trx2).{65926,55482} In the presence of high concentrations of hydrogen peroxide, Cp is oxidized to sulfinic acid (C-SO2H), which can be reduced by sulfiredoxin (Srx), or the irreversible sulfonic acid (C-SO3H) species.{65926} Knockout of the gene encoding thioredoxin reductase 2 (TrxR2) increases the levels of SO3-Prx3 in isolated mouse embryonic endothelial progenitor cells.{55482} Hyperoxidized Prx3 (SO2/3-Prx3) is also increased during ferroptosis induced by erastin or RSL3 in vitro.{68575} Liver levels of SO2/3-Prx3 are increased in mouse models of alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). Cayman’s Hyperoxidized Peroxiredoxin-3 Polyclonal Antibody can be used for ELISA, immunofluorescence (IF), and Western blot (WB) applications. The antibody recognizes hyperoxidized Prx3 at approximately 23 kDa from human samples.
反应种属:
宿主来源:

Rabbit
实验应用:

ELISA, IF, WB
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免疫原:

A hyperoxidized human Prx3 peptide sequence
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-20
运输温度:

-80
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产品形式:

100 µg of protein A-affinity purified polyclonal antibody
存储溶液:
有效期:

365
产地:

美国
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