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产品名称:
GDNF Antibody: ATTO 488
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别名:
Glial cell line-derived neurotrophic factor Antibody, Astrocyte-derived trophic factor Antibody, Astrocyte derived trophic factor 1 Antibody, Glial cell derived neurotrophic factor Antibody, ATF 1 Antibody, ATF 2 Antibody, Glial Cell Line Derived Neurotrophic Factor Antibody, ATF Antibody, Atf Antibody, HSCR3 Antibody, Astrocyte derived trophic factor Antibody, ATF2 Antibody, GDNF_HUMAN Antibody, GDNF Antibody, Glial derived neurotrophic factor Antibody, ATF1 Antibody, gdnf Antibody, HFB1 GDNF Antibody, hGDNF Antibody
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产品描述:
Rabbit Anti-Human GDNF Polyclonal
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反应种属:
Human | Mouse | Rat
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宿主来源:
Rabbit
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实验应用:
WB
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
Recombinant Human GDNF Protein, Full length (AA78-211)
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免疫原种属:
Human
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克隆性:
Polyclonal
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克隆号:
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纯化方式:
Protein A Purified
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偶联:
ATTO 488
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产品浓度:
1mg/mL
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表达系统:
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阳性对照:
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保存温度:
Conjugated antibodies should be stored according to the product label
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运输温度:
Blue Ice or 4ºC
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细胞定位:
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产品形式:
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存储溶液:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Glial cell line-derived neurotrophic factor (GDNF), a highly conserved multifunctional secretory protein, is distributed throughout the peripheral and central nervous system to support neuronal growth, proliferation, and survival (1-3). It was the first member of the GDNF family ligands (GFL). Pro-GDNF, a 211 residue precursor sequence, folds via disulphide bonding and dimerization in the endoplasmic reticulum (ER). N-linked glycosylation subsequently takes place at the tip of one of the protein’s two finger-like structures. These structures facilitate contact between the mature protein, the GRFα1 receptor, and RET, that is necessary for GDNF signalling. A similar configuration is observed in the cytokine TGFβ2 (2). The mature GDNF protein (134 residues) is produced by proteolysis of processed pro-GDNF at a proteolytic consensus sequence situated within the C-terminus (1). Through interactions between Cys131, Cys133, Cys68 & Cys72, the C-terminus forms a ring-like structure (3). As multiple proteases can cleave the precursor sequence, different forms of mature GDNF are possible (1). GDNF is implicated in the promotion of dopamine uptake within midbrain dopaminergic neurons, as well as the proliferation and migration of gliomas. Motor neurons, Schwann cells, oligodendrocytes, astrocytes, and skeletal muscle have been shown to secrete GDNF during neuronal development and growth (1,3). Initial studies suggested that GDNF may play a neuroprotective role in neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease and various synucleinopathies (4,5), however, recent research has indicated inconsistent levels of neuroprotective ability in neurodegenerative disease models (1, 6-8).
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样本类型:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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