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产品名称:
E-Cadherin antibody
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别名:
cadherin 1 , Arc-1 , BCDS1 , CD324 , CDHE , ECAD , LCAM , UVO
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产品描述:
E-Cadherin antibody detects E-cadherin protein, which is encoded by the CDH1 gene. E-cadherin is a calcium-dependent cell adhesion protein (predicted molecular weight of 97 kDa) that plays a vital role in cell migration and proliferation. Because E-cadherin is an epithelial cell marker, this antibody is a well-published and widely used reagent to study E-cadherin protein expression during the epithelial-mesenchymal transition (EMT) in various physiological and pathological processes.
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反应种属:
Dog, Human, Mouse, Rat, Zebrafish
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宿主来源:
Rabbit
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实验应用:
ICC/IF, IHC-P, IHC-Wm, IP, PLA, WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
Recombinant protein encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.
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免疫原种属:
Human
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克隆性:
Polyclonal
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克隆号:
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纯化方式:
Purified by antigen-affinity chromatography.
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偶联:
Unconjugated
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产品浓度:
0.14 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
97
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产品形式:
Liquid
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存储溶液:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
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有效期:
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产地:
美国
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外观:
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功能与背景:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]
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样本类型:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
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