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产品名称:
N-Cadherin antibody
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别名:
cadherin 2 , CD325 , CDHN , CDw325 , NCAD
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产品描述:
N-Cadherin antibody recognizes N-cadherin protein, a calcium-dependent cell adhesion protein (predicted molecular weight of 100 kDa) encoded by the CDH2 gene. N-cadherin is involved in multiple processes, including neuron development and epithelial-mesenchymal transition (EMT). Due to the prominent role of EMT in cancer progression and metastasis, antibodies targeting either N-cadherin or E-cadherin are frequently used together to study the EMT process: the upregulation of N-cadherin followed by the downregulation of E-cadherin.
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反应种属:
Human, Monkey, Mouse, Rat
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宿主来源:
Rabbit
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实验应用:
ICC/IF, IHC-Fr, IHC-P, WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
Synthetic peptide encompassing a sequence within the Intracellular domain of human N-Cadherin. The exact sequence is proprietary.
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免疫原种属:
Human
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克隆性:
Polyclonal
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克隆号:
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纯化方式:
Purified by antigen-affinity chromatography.
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偶联:
Unconjugated
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产品浓度:
0.15 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
100
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产品形式:
Liquid
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存储溶液:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
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有效期:
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产地:
美国
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外观:
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生产商:
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功能与背景:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq]
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URL:
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检测方法:
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样本类型:
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
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