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产品名称:
SMAD2 antibody
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别名:
SMAD family member 2 , JV18 , JV18-1 , MADH2 , MADR2 , hMAD-2 , hSMAD2
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产品描述:
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反应种属:
Human, Mouse, Rat
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宿主来源:
Rabbit
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实验应用:
ICC/IF, IHC-P, WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
Recombinant protein encompassing a sequence within the center region of human SMAD2. The exact sequence is proprietary.
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免疫原种属:
Human
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克隆性:
Polyclonal
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克隆号:
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纯化方式:
Purified by antigen-affinity chromatography.
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偶联:
Unconjugated
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产品浓度:
0.55 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
52
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产品形式:
Liquid
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存储溶液:
0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
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有效期:
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产地:
美国
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外观:
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生产商:
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功能与背景:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
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URL:
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灵敏度:
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检测方法:
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样本类型:
0.1M Tris, 0.1M Glycine, 20% Glycerol, 0.01% Thimerosal.
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产品特点:
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纯度:
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生物活性:
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来源:
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Accession #:
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CAS号:
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PubChem CID: