产品描述:
N-Acetyl Ser-Asp-Lys-Pro (AcSDKP) is a tetrapeptide growth regulatory hormone which inhibits the proliferation of hematopoietic stem cells.{9035} The dipeptidase Angiotensin Converting Enzyme (ACE) actively metabolizes circulating AcSDKP, giving it a brief plasma half life of 4 to 5 minutes. ACE inhibition is a major therapeutic end point in the treatment of hypertension management. A further consequence of ACE inhibition is the accumulation of AcSDKP in the plasma and the urine.{9036,9037} This accumulation may have physiological effects, which are manifested as the anemia of chronic ACE inhibitor toxicity. More commonly, plasma and urine AcSDKP levels can be used as a biomarker of ACE inhibition and an index of patient compliance with therapy.{9038} Measurement of AcSDKP in human urine or plasma can be readily accomplished by enzyme immunoassay.{9040} [Bertin Catalog No. A05881]