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Recombinant Human IGF-BP4
品牌： PeproTech
产品货号： 350-05B-5ug
规格： 5ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Recombinant Human IGF-BP4
  • 别名:
    Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor
  • 产品描述:
    IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF-independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant Human IGF-BP4 is a 25.7 kDa protein consisting of 237 amino acid residues including, the IGF-BP domain and thyroglobulin type-I domain.
  • 反应种属:
  • 宿主来源:
    (BTI-Tn-5B1-4) Hi-5 Insect cells
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  • 推荐稀释度:
    请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
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  • 预期分子量:
    25.7 kDa
  • 产品形式:
    Standard
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  • 产地:
    美国
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