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蛋白质,酶与肽
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重组蛋白
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细胞因子、趋化因子与生长因子
Recombinant Human Visfatin
品牌:
PeproTech
产品货号:
130-09-250ug
规格:
250ug
报价:
折后价:
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* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
Recombinant Human Visfatin
别名:
PBEF (Pre-B cell colony-enhancing factor), NAmPRTase (nicotinamide phosphoribosyltransferase), Nampt, VF
产品描述:
Visfatin is a 55 kDa protein produced and secreted primarily by white adipose tissue. Recently, visfatin was isolated from visceral fat deposits and shown to possess insulin-mimetic activity. Like insulin, visfatin exerts hypoglycemic effects by interacting with the insulin receptor. The binding affinity of visfatin for the insulin receptor is similar to that of insulin, but it does not compete with insulin, suggesting that the two proteins interact with different receptor sites. The circulating levels of visfatin are much lower than those of insulin and are not affected by feeding, implying that the hypoglycemic effect of visfatin may not be of physiological importance. The plasma visfatin levels, like those of leptin, correlate positively with the percent of body fat, and increase during the development of obesity. Another similarity between visfatin and leptin is that their amino acid sequence is highly conserved across different mammalian species and shows no homology to any known protein. Receptors for both leptin (Ob-R) and visfatin (i.e. the insulin receptor) are expressed by neurons within the arcuate nucleus of the hypothalamus, a brain area that plays a pivotal role in the regulation of energy metabolism. Although the metabolic function of visfatin is still unknown, it appears that this newly identified adipocytokine might play an important role, similar to that of leptin, in the regulation of body weight, i.e. as an afferent signal reflecting excess body fat. The PBEF gene encodes a polypeptide of 491 amino acid residues. The secreted form of this polypeptide, i.e. visfatin, contains 465 residues and lacks the 26 amino acid signal sequence of the PBEF gene product. The 491-residue form has been shown to be a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. The amino acid sequence of visfatin is highly conserved across different species and shows no homology to any known protein. It contains 5 cysteine residues, of which only two of them appear to be involved in disulfide bridge formation. Recombinant human Visfatin is a 52.6 kDa protein containing 466 amino acid residues (isoform 1).
反应种属:
宿主来源:
E.coli
实验应用:
靶标/特异性:
同种型:
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
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产品浓度:
表达系统:
阳性对照:
保存温度:
运输温度:
细胞定位:
预期分子量:
52.6 kDa
产品形式:
Bulk
存储溶液:
有效期:
产地:
美国
外观:
生产商:
功能与背景:
URL:
灵敏度:
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检测方法:
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最新促销
+
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