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Recombinant Human sIL-6 Receptor alpha (CHO derived)
品牌： PeproTech
产品货号： 200-06RC-500ug
规格： 500ug

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数量： - +
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  • 产品名称:
    Recombinant Human sIL-6 Receptor alpha (CHO derived)
  • 别名:
    soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
  • 产品描述:
    IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ralpha and gp130. While the IL-6Ralpha chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Ralpha. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ralpha alone. IL-6Ralpha is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Ralpha, which consists of only the extracellular domain of the IL-6Ralpha chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor alpha is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Ralpha. As a result of glycosylation, Recombinant Human sIL-6 Receptor alpha migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.
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  • 宿主来源:
    CHO cells
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  • 推荐稀释度:
    请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
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  • 预期分子量:
    37.9 kDa
  • 产品形式:
    Bulk
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  • 产地:
    美国
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