SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain N501Y variant (rabbit IgG1 Fc-tagged)

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品牌： Cayman

产品货号： 33867

规格： 100 µg

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数量： - +

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产品名称:

SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain N501Y variant (rabbit IgG1 Fc-tagged)
别名:

SARS-CoV-2 Spike RBD|SARS-CoV-2 Spike Receptor Binding Domain|Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein Receptor Binding Domain|Spike S1 RBD|UK Variant|WHO Label: Alpha
产品描述:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.{53462,53459,53461,55257,55258} The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion.{53462} It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.{46767,49561} The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.{49542,49536,49558} In this way, ACE2 acts as the functional receptor for SARS-CoV-2. The asparagine-to-tyrosine substitution at position 501 (N501Y) is located within the spike glycoprotein RBD and increases SARS-CoV-2 affinity for human ACE2, which may increase virus transmissibility.{60562} This mutation is shared by three SARS-CoV-2 variants of concern (VOC): B1.1.7, P.1, and B.1.351, originally identified in the United Kingdom, Brazil, and South Africa, respectively. Cayman’s SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain N501Y variant (rabbit IgG1 Fc-tagged) protein can used for ELISA, surface plasmon resonance (SPR), and Western blot (WB) applications.
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保存温度:

-80
运输温度:

-80
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PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% polysorbate 20, and 10% glycerol
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365
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美国
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≥90% estimated by SDS-PAGE
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