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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.{53462,53459,53461} The SARS-CoV-2 genome contains approximately 30 kilobases and 14 open reading frames (ORFs) that encode four structural proteins: spike, envelope, membrane, and nucleocapsid, as well as 16 non-structural proteins and nine accessory factors.{57176} The SARS-CoV-2 envelope protein (E protein) is composed of an N-terminal domain, a transmembrane domain, and a C-terminal domain, which contains three conserved cysteine residues (C40, C43, and C44) that are post-translationally palmitoylated in a similar virus, SARS-CoV.{66724,66725} It localizes to the Golgi, endoplasmic reticulum (ER), and ER-Golgi intermedium compartment (ERGIC) of SARS-CoV-2 infected cells and homo-oligomerization of the E protein forms a pH-sensitive, cation-selective ion channel, also known as a viroporin.{66726,66724} It is involved in morphogenesis, viral assembly, and maturation and retention of the spike glycoprotein, also known as surface glycoprotein.{66724,66729} SARS-CoV-2 E protein is acetylated by the histone acetyltransferase p300, and acetylated SARS-CoV-2 E protein binds to bromodomain-containing protein 4 (BRD4).{66730} Intravenous administration of recombinant SARS-CoV-2 E protein induces spleen edema, as well as pulmonary inflammatory cell infiltration, edema, interstitial hyperemia, hemorrhage, and alveolar collapse in mice.{66731} Cayman’s SARS-CoV-2 Envelope Protein (C40A, C43A, C44A mutant; recombinant) protein consists of 475 amino acids and has a calculated molecular weight of 52.2 kDa.