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Zika Virus NS5 Protein (strain Zika SPH2015) (recombinant)
品牌： Cayman
产品货号： 41079
规格： 100 µg

报价：
折后价：

数量： - +
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  • 产品名称:
    Zika Virus NS5 Protein (strain Zika SPH2015) (recombinant)
  • 别名:
    ZIKV Non-structural Protein 5|ZIKV-NS5
  • 产品描述:
    Zika virus (ZIKV) is a mosquito-borne, positive-stranded RNA virus and a member of the Flavivirus genus.{31923,72406} ZIKV infection is associated with fever, rashes, and conjunctivitis, as well as more severe symptoms, which include Guillain-Barré syndrome in adults and microcephaly or congenital malformations in fetuses and newborns.{31923,72408} The single-stranded RNA genome of ZIKV is translated as a polypeptide, which is cleaved by host and viral proteases into structural capsid (C), precursor membrane (prM), and envelope (E) proteins and seven non-structural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5.{31923,72407} ZIKV NS5 is composed of an N-terminal methyltransferase (MTase) domain involved in 5’ RNA capping prior to translation, a short linker region, and a C-terminal RNA-dependent RNA polymerase (RdRp) domain required for viral RNA replication.{68795,68796,68797} ZIKV NS5 inhibits host IFN signaling by binding to the human, but not mouse, transcriptional activator STAT2 and targeting it for proteasomal degradation.{68798,68797} Cayman's Zika virus NS5 (strain Zika SPH2015) (recombinant) protein consists of 663 amino acids and has a calculated molecular weight of 76.7 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 64 kDa.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    Sterile 20 mM PB,100 mM sodium chloride, 50% glycerol, pH 7.0, 0.5 mM TCEP
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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    ≥85% estimated by SDS-PAGE
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