SDF-1alpha [CXCL12] (human):Fc (human) (rec.) - 深圳欣博盛生物科技有限公司

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SDF-1alpha [CXCL12] (human):Fc (human) (rec.)

品牌： Adipogen

产品货号： CHI-HF-210SDF1A-C050

规格： 50 ug

报价：

折后价：

数量： - +

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产品名称:

SDF-1alpha [CXCL12] (human):Fc (human) (rec.)
别名:

CXCL12; C-X-C Motif Chemokine 12; PBSF; SCYB12; TLSF; TPAR1
产品描述:

The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine that belongs to the CXC chemokine subfamily. SDF1 is widely expressed in various organs including heart, liver, brain, kidney, skeletal muscle, and lymphoid organs, and is highly conserved between species. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1alpha and SDF1beta, which are identical except for the four residues present in the C-terminus of SDF1beta but absent from SDF1alpha. As a highly efficacious lymphocyte chemoattractant, SDF1 activates and directs the migration of leukocytes in response to proinflammatory stimuli such as LPS, TNF, or interleukins. It has been demonstrated that SDF1 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and thus plays an important role in carcinoma pathogenesis. In addition, SDF1 is identified as the biological ligand for CXC-chemokine receptor 4 (CXCR4), which is widely expressed in leukocytes and acts as the cofactor for HIV-1 entry, and inhibits the HIV-1 infection. Furthermore, SDF1 is rapidly inactivated via N-terminal processing by cathepsin G associated with the membrane of B-cells, NK cells and to a lesser extent, T-cells.
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HEK 293 cells
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保存温度:

-20°C
运输温度:

BLUE ICE
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预期分子量:

~35kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.
有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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瑞士
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Lyophilized from 0.2µm-filtered solution in PBS.
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纯度:

>95% (SDS-PAGE)
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