TAPA-1/CD81 Extracellular Domain (human, recombinant; His-tagged)

您现在的位置：首页 > 产品目录 > 产品分类 > 蛋白质，酶与肽 > 重组蛋白 > 其他重组蛋白

品牌： Cayman

产品货号： 37019

规格： 100 µg

报价：

折后价：

数量： - +

问题咨询

官网链接

说明书

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TAPA-1/CD81 Extracellular Domain (human, recombinant; His-tagged)
别名:

CVID6|TAPA-1|Target of Antiproliferative Antibody 1|TSPAN28
产品描述:

CD81, also known as target of antiproliferative antibody 1 (TAPA-1), is a member of the tetraspanin protein family with roles in B cell biology and T cell activation and as a virus host factor.{66258,66261} It is composed of four transmembrane segments, which are packed as two pairs of helices, and an extracellular loop at the outer membrane leaflet that, unlike other tetraspanin proteins, is non-glycosylated and subject to post-translational acylation.{66261,66256} On the surface of B cells, CD81 associates with CD19 and CD21 to facilitate adhesion and reduce the threshold for B cell receptor activation, as well as with MHC class II molecules as a component of the B cell surface receptor complex.{66256,66260,66255} On T cells, CD81 interacts with CD4 and CD8 and functions as a co-stimulator of naïve T cell activation in conjunction with CD3 and CD28.{66258,66259} CD81 also acts as a virus host factor, and neutralization of CD81 with anti-CD81 antibodies reduces HIV-1 replication and inhibits influenza A virus uncoating and viral budding, as well as inhibits coronavirus (CoV) and hepatitis C virus (HCV) cell entry.{66257} CD81 levels are increased in several lymphoma cell lines, and antibody-driven neutralization of CD81 induces complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and cytotoxicity in these cells.{66255} Cayman’s TAPA-1/CD81 Extracellular Domain (human, recombinant; His-tagged) protein consists of 108 amino acids and has a calculated molecular weight of 12.1 kDa.
反应种属:
宿主来源:
实验应用:
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-80
运输温度:

-80
细胞定位:
预期分子量:
产品形式:
存储溶液:
有效期:

365
产地:

美国
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:
产品特点:
纯度:

≥90% estimated by SDS-PAGE
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: