TIM-4 Extracellular Domain (human, recombinant) - Biotinylated - 深圳欣博盛生物科技有限公司

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TIM-4 Extracellular Domain (human, recombinant) - Biotinylated

品牌： Cayman

产品货号： 37098-100 µg

规格： 100 µg

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折后价：

数量： - +

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产品名称:

TIM-4 Extracellular Domain (human, recombinant) - Biotinylated
别名:

T Cell Immunoglobulin and Mucin Domain-containing Protein 4|T Cell Immunoglobulin Mucin Receptor 4|T Cell Membrane Protein 4|TIMD-4
产品描述:

TIM-4 is a type I transmembrane protein and member of the T cell immunoglobulin and mucin domain-containing (TIM) family of immunoregulatory proteins.{21964} It is composed of an N-terminal immunoglobulin variable (IgV) domain that binds to phosphatidylserine, as well as a mucin stalk, which contains O- and N-linked glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic tail, which lacks a tyrosine phosphorylation site, unlike TIM-1 and TIM-3.{15136,21964} TIM-4 is expressed in antigen-presenting cells (APCs) such as dendritic cells and macrophages and binds to TIM-1 on activated T cells.{21967} It is mainly involved in phagocytosis of apoptotic cells via recognition of phosphatidylserine, but also plays a role in T cell proliferation and survival, viral entry, and antitumor immunity.{15136,29982,67258,67259} TIM-4 targeting antibodies prevent HIV-1 entry into host cells in vitro and enhance the efficacy of anticancer vaccines in a murine melanoma model.{67258,67259} SNPs in TIMD4 are associated with increased susceptibility of asthma in children.{21966} Cayman's TIM-4 Extracellular Domain (human, recombinant) - Biotinylated protein consists of 302 amino acids, has a calculated molecular weight of 32.7 kDa, and a predicted N-terminus of Glu25 after signal peptide cleavage. By SDS-PAGE, the apparent molecular mass of the protein is approximately 60 kDa due to glycosylation.
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-80
运输温度:

-80
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Lyophilized from sterile PBS, pH 7.4
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365
产地:

美国
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≥90% as determined by SDS-PAGE
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