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Neuregulin-1 Type I-β2b Extracellular Domain (human, recombinant; aa 20-238)
品牌： Cayman
产品货号： 32094-100 µg
规格： 100 µg

报价：
折后价：

数量： - +
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  • 产品名称:
    Neuregulin-1 Type I-β2b Extracellular Domain (human, recombinant; aa 20-238)
  • 别名:
    Heregulin β2b|HRG-β2b|NDF-β2b|Neu Differentiation Factor β2b|NRG1 Type I Isoform β2b|NRG1-β2b
  • 产品描述:
    Neuregulin-1 type I-β2b is a trophic factor and member of the neuregulin-1 family of growth factors, which comprises greater than 30 isoforms grouped into types I through VI based on their N-terminal region, which is generated by alternative splicing of NRG1.{69199} It is composed of a type I N-terminal domain, an immunoglobulin-like (Ig-like) domain, a glycosylated domain, an EGF-like domain, a linker region that contains a proteolytic cleavage site to release the mature protein, a transmembrane domain, and a cytoplasmic tail.{69199,69200} The type I-β2b splice variant of Nrg1 is mainly expressed in the brain and stomach but is also expressed at low levels in most tissues.{69200} Neuregulin-1 signaling is mediated by homodimers of HER4 and the heterodimers HER2-HER3, HER2-HER4, HER3-HER4, and EGFR-HER4.{69199} The cytoplasmic domain of neuregulin-1 type I-β2b induces apoptosis in breast cancer cells, and the mature protein induces apoptosis in fibroblasts in vitro.{69201,69200} This protein consists of 230 amino acids and has a calculated molecular weight of 25.3 kDa. By SDS-PAGE, the apparent molecular mass of the protein is approximately 45 kDa due to glycosylation.
  • 反应种属:
  • 宿主来源:
    HEK293 cells
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  • 阳性对照:
  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    Lyophilized from sterile PBS, pH 7.4
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥95% estimated by SDS-PAGE
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