IL-7 (human) (monomeric):Fc-KIH (human) (rec.) - 深圳欣博盛生物科技有限公司

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IL-7 (human) (monomeric):Fc-KIH (human) (rec.)

品牌： Adipogen

产品货号： AG-40B-0238-C050

规格： 50 ug

报价：

折后价：

数量： - +

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产品名称:

IL-7 (human) (monomeric):Fc-KIH (human) (rec.)
别名:

IL-7 (human) (monomeric):Fc Knobs-into-Holes (human) (rec.); Interleukin-7; Lymphopoietin 1; LP1
产品描述:

Interleukin-7 (IL-7) is a hematopoietic growth factor and a member of the IL-7/IL-9 family, which is produced by fetal liver cells, stromal cells in the bone marrow (BM), thymus and other epithelial cells, including keratinocytes and enterocytes. The receptor of IL-7, IL-7R, is a heterodimeric complex consisting of the alpha-chain (CD127) and the common cytokine receptor gamma-chain, shared with the receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, and expressed in a variety of cells. IL-7 has a critical developmental function at every stage of T cell development, for both alphabeta and gammadelta lineages, and for the development and survival of naive T cells as well as generation and maintenance of CD4 and CD8 memory. IL-7 is also essential for the development and maintenance of the new ILCs. IL-7 is important throughout hematopoiesis, facilitating key lineage fate decisions. IL-7 is thought to support aberrant immune activity in autoimmune diseases such as diabetes and multiple sclerosis and in chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis and inflammatory bowel disease. IL-7 contributes to leukemia development in vivo and also stimulates multiple immune-mediated mechanisms that contribute to the eradication of tumors. The protein IL-7 (human) (monomeric):Fc-KIH (human) (rec.) is produced by using two different vectors, one encoding for the IL-7 (human):Fc Knobs sequence (synthesizing a protein of 60kDa) and one encoding for the Fc Holes sequence (synthesizing a protein of 28kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization of the Fc moieties and for secretion of the final protein IL-7 (human) (monomeric):Fc-KIH (human) (rec.).
反应种属:
宿主来源:

HEK 293 cells
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免疫原:
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产品浓度:

After reconstitution: 1mg/ml
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~60kDa and 28kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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Lyophilized. Contains PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
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