IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.) - 深圳欣博盛生物科技有限公司

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IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.)

品牌： Adipogen

产品货号： AG-40B-0241-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.)
别名:

IL-38 (human) (monomeric):Fc Knobs-into-Holes (human) (rec.); Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
产品描述:

IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus. The protein IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.) is produced by using two different vectors, one encoding for the IL-38 (aa 1-152) (human):Fc Knobs sequence (synthesizing a protein of 45kDa) and one encoding for the Fc Holes sequence (synthesizing a protein of 28kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization of the Fc moieties and for secretion of the final protein IL-38 (aa 1-152) (human)(monomeric):Fc-KIH (human) (rec.).
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宿主来源:

HEK 293 cells
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产品浓度:

After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1mg/ml
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阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
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预期分子量:

~53kDa and 28kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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Lyophilized. Contains PBS.
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纯度:

>95% (SDS-PAGE)
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