Tau dGAE (297-391) AD-mimic Pre-formed Fibrils - 深圳欣博盛生物科技有限公司

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Tau dGAE (297-391) AD-mimic Pre-formed Fibrils

品牌： Stressmarq

产品货号： SPR-502E

规格： 100 µg x5

报价：

折后价：

数量： - +

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产品名称:

Tau dGAE (297-391) AD-mimic Pre-formed Fibrils
别名:

Tau aggregate, Tau PFFs, Tau PFF, Tau protein aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, dGAE Tau Protein, Tau dGAE
产品描述:

Human Recombinant Tau dGAE (297-391) AD-mimic Pre-formed Fibrils (fibrilized without heparin)
反应种属:

Human
宿主来源:
实验应用:

WB | In vivo Assay | In vitro Assay
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:

Ion-exchange Purified
偶联:

No Tag
产品浓度:

2 mg/ml or 5 mg/ml
表达系统:

E. coli
阳性对照:
保存温度:

-80ºC
运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
细胞定位:
预期分子量:

10.165 kDa
产品形式:
存储溶液:

10mM PB pH 7.4, 10mM DTT, 200mM MgCl2
有效期:
产地:

加拿大
外观:
生产商:
功能与背景:

Filamentous tau inclusions are a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE), collectively called tauopathies. Advances in Cryo-EM have revealed that tau filaments isolated from individuals with a particular neurodegenerative disease share a distinct tau fold – i.e. an AD-isolated Tau filaments’ fold is distinct from a CTE-isolated Tau filaments’ fold (1-3). Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. Recent Cryo-EM studies have demonstrated that recombinantly generated Tau dGAE monomers will form the disease-isolated AD or CTE Tau filament folds under highly specific conditions in vitro (4, 5). StressMarq’s catalog# SPR-502 Tau dGAE (297-391) AD-mimic PFFs are purified and fibrilized under these exact published conditions that replicate the disease-isolated AD-fold (200 rpm at 37oC in 10 mM PB 10 mM DTT pH 7.4 200 mM MgCl2 for 48 hours).
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

10mM PB pH 7.4, 10mM DTT, 200mM MgCl2
产品特点:
纯度:

>95%
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: