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Recombinant Human sIL-12 Receptor beta-1 Fc
品牌： PeproTech
产品货号： 200-12RB-1-1mg
规格： 1mg

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数量： - +
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  • 产品名称:
    Recombinant Human sIL-12 Receptor beta-1 Fc
  • 别名:
    soluble IL‐12 receptor subunit beta‐1, soluble IL‐12 receptor beta‐1, soluble IL‐12R beta‐1, soluble IL12RB1, IL‐12R, CD212
  • 产品描述:
    The IL‐12 structurally related family of heterodimeric proteins plays an important role in activating, regulating, and modulating the immune response. This family of proteins transmits its activity through receptors, which, when stimulated by ligand binding, generally activate JAK proteins that subsequently phosphorylate STAT transcription factors. IL‐12R beta‐1 is a single pass membrane protein expressed on T cells, B cells, and NK cells. By itself, IL‐12R beta‐1 binds to IL‐12 with low affinity, but when paired with IL‐12R beta‐2, forms a high affinity IL‐12 receptor. IL‐12R beta‐1 can also pair with IL‐23R to form a high affinity receptor for IL‐23. Recombinant Human sIL‐12 Receptor beta‐1 Fc has a calculated molecular weight of 84.3 kDa and contains 758 amino acid residues, which consists of the extracellular domain of IL‐12R beta‐1 fused to the Fc portion of human IgG and contains a C‐terminal His‐tag. Due to glycosylation, it migrates at an approximate molecular weight of 116 kDa, under reducing conditions.
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    CHO cells
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    84.3 kDa
  • 产品形式:
    Bulk
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  • 产地:
    美国
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