Fc (LALA-PG)-KIH (human):Irisin (monomeric) (rec.) - 深圳欣博盛生物科技有限公司

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Fc (LALA-PG)-KIH (human):Irisin (monomeric) (rec.)

品牌： Adipogen

产品货号： AG-40B-0246-C050

规格： 50 ug

报价：

折后价：

数量： - +

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产品名称:

Fc (LALA-PG)-KIH (human):Irisin (monomeric) (rec.)
别名:

Fc (LALA-PG)-KIH (human):Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)
产品描述:

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. Upon exercise, FNDC5 expressed by skeletal muscles is proteolytically processed and secreted as the myokine Irisin, which has several functions: i) it contributes to the conversion of white fat to higher oxygen consumable brown fat (also called beige fat) in response to exercise; ii) it regulates bone mineral density and bones remodeling; and iii) it increases synaptic plasticity and rescues memory and cognitive function of the brain in mouse models of Alzheimer’s disease. Irisin not only plays a vital role in energy metabolism but also has crucial roles in a variety of processes such as inflammation, proliferation, metastasis, aging and neural differentiation. The protein Fc (LALA-PG)-KIH (human):Irisin (monomeric) (rec.) is produced by using two different vectors, one encoding for the Fc Knobs (LALA-PG) (human):Irisin sequence (synthesizing a protein of 55kDa) and one encoding for the Fc Holes (LALA-PG) sequence (synthesizing a protein of 30kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization and for secretion of the final protein Fc (LALA-PG)-KIH (human):Irisin (monomeric) (rec.). The Fc contains the mutations LALA-PG that abolish the interaction between the Fc and FcgammaRs and therefore Fc undesirable effects.
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宿主来源:

HEK 293 cells
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产品浓度:

1mg/ml after reconstitution.
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
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预期分子量:

~55kDa and 30 kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS
有效期:

Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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Lyophilized. Contains PBS
产品特点:
纯度:

>95% (SDS-PAGE)
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