您好，欢迎光临欣博盛生物科技商城！
服务热线：400 680 0892
购物车图片 购物车 ( )
Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)
品牌： Stressmarq
产品货号： SPR-515XE
规格： 500 µg (@5mg/ml)

报价：
折后价：

数量： - +
问题咨询
官网链接
说明书
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)
  • 别名:
    MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
  • 产品描述:
    Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers (CHO-expressed, N-glycosylated)
  • 反应种属:
    Human
  • 宿主来源:
  • 实验应用:
    WB | In vivo Assay | In vitro Assay
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
  • 纯化方式:
    Affinity Purified and Size Exclusion
  • 偶联:
    N-term histidine tag & TEV site
  • 产品浓度:
    2 mg/ml or 5 mg/ml
  • 表达系统:
    Chinese Hamster Ovary (CHO)
  • 阳性对照:
  • 保存温度:
    -80ºC
  • 运输温度:
    Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
  • 细胞定位:
  • 预期分子量:
    48.609 kDa
  • 产品形式:
  • 存储溶液:
    1X PB pH 7.4
  • 有效期:
  • 产地:
    加拿大
  • 外观:
  • 生产商:
  • 功能与背景:
    Mammalian N-glycosylation is present on CHO-secreted tau 2N4R, which contributes to slower migration on SDS-PAGE than E.coli or Baculovirus/Sf9 expressed tau (1, 2). N-glycosylated tau has been identified in human AD-diseased brains, but not healthy brains, and may precede tau hyperphosphorylation (3, 4). N-glycosylation of Tau has been demonstrated to affect its aggregation propensity (5). The tau P301S mutation is associated with early onset neurodegeneration, and functionally reduces microtubule assembly and stimulates fibril assembly (6, 7). Our CHO-expressed Tau 2N4R P301S will readily form fibrils in the absence of heparin and contains mammalian post-translational modifications that may better mimic tau in human AD-brains.
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    1X PB pH 7.4
  • 产品特点:
  • 纯度:
    >95%
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
粤ICP备08007346号
  网站地图
犀牛云提供企业云服务