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Alpha Synuclein S87N Mutant Pre-formed Fibrils
品牌： Stressmarq
产品货号： SPR-500XE
规格： 500 µg (@5mg/ml)

报价：
折后价：

数量： - +
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  • 产品名称:
    Alpha Synuclein S87N Mutant Pre-formed Fibrils
  • 别名:
    MAPT, 2N4R, Tau40 neurofibrillary tangle protein, paired-helical filament, PHFs, SNCA, NACP, PARK1, asyn, alpha-synuclein, pre-formed fibril, PFFs, mixed fibrils
  • 产品描述:
    Human Recombinant Alpha Synuclein S87N Mutant Pre-formed Fibrils
  • 反应种属:
    Human
  • 宿主来源:
  • 实验应用:
    WB | In vivo Assay | In vitro Assay
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
  • 纯化方式:
    Ion-exchange Purified
  • 偶联:
    No Tag
  • 产品浓度:
    2 mg/ml or 5 mg/ml
  • 表达系统:
    E. coli
  • 阳性对照:
  • 保存温度:
    -80ºC
  • 运输温度:
    Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
  • 细胞定位:
  • 预期分子量:
    14.46 kDa
  • 产品形式:
  • 存储溶液:
    1X PBS pH 7.4
  • 有效期:
  • 产地:
    加拿大
  • 外观:
  • 生产商:
  • 功能与背景:
    Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing endogenous mouse α-syn pathology (1). A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro (2,3). Chimeric HuS87N fibrils show enhanced induction of α-syn pathology greater than both HuWT and MsWT fibrils in mice neuron cultures (4). Therefore, HuS87N is a good construct for inducing robust endogenous α-syn seeding and pathology in wild-type mice/cultures.
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    1X PBS pH 7.4
  • 产品特点:
  • 纯度:
    >95%
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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