Ninjurin-1 Extracellular Domain (rat, recombinant) - 深圳欣博盛生物科技有限公司

您现在的位置：首页 > 产品目录 > 产品分类 > 蛋白质，酶与肽 > 重组蛋白 > 其他重组蛋白

Ninjurin-1 Extracellular Domain (rat, recombinant)

品牌： Cayman

产品货号： 41069

规格： 100 µg

报价：

折后价：

数量： - +

问题咨询

官网链接

说明书

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ninjurin-1 Extracellular Domain (rat, recombinant)
别名:

Nerve Injury-induced Protein 1|NINJ1
产品描述:

Ninjurin-1 is a type 3b transmembrane protein and adhesion molecule.{67783} It is composed of an N-terminal extracellular domain containing a region required for homophilic binding, two transmembrane domains, a short intracellular region, and a second extracellular domain at the C-terminal.{67783,67784} The N-terminal extracellular domain can be cleaved by matrix metalloprotease-9 (MMP-9) to release soluble ninjurin-1 (sNinj1).{67785} Ninjurin-1 is expressed in Schwann cells, neurons, and certain activated immune cells, including macrophages and T cells, as well as embryonic and adult epithelial tissues.{67783,67786} It is involved in cell adhesion, axonal growth, and chemotaxis, as well as cell lysis and damage-associated molecular pattern (DAMP) molecule release during pyroptosis, among other activities.{67784,67786} NINJ1 knockout reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).{67787} The expression of Ninj1 is increased in Schwann cells and dorsal root ganglion neurons after nerve injury in rats, and ninjurin-1 is involved in peripheral nerve regeneration after sciatic nerve injury in mice.{67786,67788} An A-C reversal in the third exon of NINJ1, which results in an aspartate-to-alanine mutation, increases the likelihood of developing nerve damage in patients with leprosy.{67786} Serum levels of sNinj1 are increased in patients with hepatocellular carcinoma and are positively correlated with tumor size, cancer stage, and metastasis.{67785} Cayman’s Ninjurin-1 Extracellular Domain (rat, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of ninjurin-1 (amino acids 1-79) fused to human IgG1 Fc at its N-terminus, consists of 340 amino acids and has a calculated molecular weight of 37 kDa. As a result of glycosylation, the monomer migrates at approximately 50 kDa by SDS-PAGE under reducing conditions.
反应种属:
宿主来源:
实验应用:
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-80
运输温度:

-80
细胞定位:
预期分子量:
产品形式:

Lyophilized from sterile PBS, pH 7.4
存储溶液:
有效期:

365
产地:

美国
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:
产品特点:
纯度:

≥95% estimated by SDS-PAGE
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: