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TEAD3 Cofactor-Binding Domain (human, recombinant)
品牌： Cayman
产品货号： 41075-500 µg
规格： 500 µg

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数量： - +
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  • 产品名称:
    TEAD3 Cofactor-Binding Domain (human, recombinant)
  • 别名:
    TEA Domain Family Member 3|TEA Domain Transcription Factor 3|TEA Domain-containing Factor 1|TEF-5|Transcriptional Enhancer Factor 5
  • 产品描述:
    TEA domain transcription factor 3 (TEAD3) is a transcription factor and member of the TEA domain-containing family of transcription factors.{51833} It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ) or YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death.{51835,51833} TEAD3 associates with VGLL3 to regulate growth and differentiation in primary mouse myoblasts and primary mouse myotubes.{51836} The tertiary structure and function of TEAD3 require C-terminal palmitoylation at residue 371.{51834} Increased tumor levels of TEAD3 are associated with decreased survival time, increased liver metastases, and reduced time of disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC).{51837} Cayman's TEAD3 Cofactor-Binding Domain (human, recombinant) protein consists of 219 amino acids, has a calculated molecular weight of 28.5 kDa, and is depalmitoylated at cysteine 371.
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    -80
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    -80
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    365
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