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SENP1 (catalytic domain) (human) (rec.) (His)
品牌： Adipogen
产品货号： SBB-DE0026-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    SENP1 (catalytic domain) (human) (rec.) (His)
  • 别名:
    Sentrin-specific Protease 1; Sentrin/SUMO-specific Protease SENP1
  • 产品描述:
    SUMO/Sentrin Specific Peptidase 1 (SENP1) is a member of the SENP family of proteases, which belong to the group of cysteine-­type peptidases. SENP1 is a SUMO-specific enzyme that catalyzes two essential functions. Processing the full-length versions of SUMO1, SUMO2 and SUMO3 into its mature forms and the deconjugation of SUMOylated proteins. SENP1 is expressed in many organs and is localized in the nucleus as well as the cytoplasm. SENP1 is thought to play a role in the development, progression and metastasis of prostate cancer and has been shown to regulate erythropoietin production during hypoxia by regulating the stability of HIF1-alpha. Furthermore, SENP1 deconjugates SUMO1 from HIPK2, HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. SENP1 has been shown to desumoylate CCAR2, which subsequently decreases the interaction with SIRT1.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 偶联:
  • 产品浓度:
    Lot dependent.
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    Dry Ice
  • 细胞定位:
  • 预期分子量:
    ~32kDa
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 10% glycerol, 1mM TCEP.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -80°C.
  • 产地:
    瑞士
  • 外观:
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  • 样本类型:
    Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 10% glycerol, 1mM TCEP.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
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