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SUMO1 (human) (rec.) (Rhodamine 110)
品牌： Adipogen
产品货号： SBB-PS0028-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    SUMO1 (human) (rec.) (Rhodamine 110)
  • 别名:
    Small Ubiquitin-related Modifier 1; GAP-modifying Protein 1; SMT3C, SMT3H3, UBL1; Sentrin; Ubiquitin-homology Domain Protein PIC1
  • 产品描述:
    SUMO1 is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. This SUMO1 substrate is C-terminally derivatized with a bis-Gly-Rhodamine 110 fluorophore. The bis-Gly-Rh110 is quenched until the amide bond between the C-terminal glycine and the bis-Gly-Rh110 compound is hydrolyzed to mono-Gly-Rhodamine 110. The efficiency of quenching combined with the powerful signal upon hydrolysis yields a reagent with unparalleled signal-to-background. SUMO1-Rh110 can be used to study the deSUMOylating activity of hydrolases SENP1 and SENP2, or other deSUMOylating enzymes. The substrate activity of SUMO1-Rhodamine 110 was determined by measuring the SENP1 catalyzed release of unquenched mono-Gly-Rh110.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 纯化方式:
  • 偶联:
    Rhodamine
  • 产品浓度:
    Lot dependent.
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    Dry Ice
  • 细胞定位:
  • 预期分子量:
    ~12kDa
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -80°C.
  • 产地:
    瑞士
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  • 样本类型:
    Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride.
  • 产品特点:
  • 纯度:
    >97% (LCMS)
  • 生物活性:
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