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Ubiquitin vinyl methyl ester (human) (rec.)
品牌： Adipogen
产品货号： SBB-PS0033-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Ubiquitin vinyl methyl ester (human) (rec.)
  • 别名:
  • 产品描述:
    Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity and promote or prevent protein interactions. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various linkage specificities. This product consists of a full-length human, mature ubiquitin polypeptide (amino acids 1-76), expressed in E.coli with a C-terminal warhead (Vinyl Methyl Ester). Ubiquitin vinyl methyl ester is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs) based on a C-terminal electrophilic vinyl methyl ester group. Ubiquitin vinyl methyl ester can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets four of the five major DUB families: UCH (Ubiquitin C-terminal hydrolases), USP (Ubiquitin specific proteases), OTU (Ovarian tumor proteases) and MJD (Machado-Josephin domain proteases) while JAMM metalloproteases are not inhibited.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 偶联:
  • 产品浓度:
    Lot dependent.
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    Dry Ice
  • 细胞定位:
  • 预期分子量:
    ~9kDa
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In 50mM MES pH 6.0, 100mM sodium chloride.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -80°C.
  • 产地:
    瑞士
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  • 样本类型:
    Liquid. In 50mM MES pH 6.0, 100mM sodium chloride.
  • 产品特点:
  • 纯度:
    >97% (LCMS)
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