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产品名称:
GRP78 (Bip) Protein
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别名:
BIP Protein, Grp78 Protein, HSPA5 Protein, MIF2 Protein, immunoglobulin heavy chain binding Protein
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产品描述:
Active Human Recombinant GRP78 (Bip) Protein
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反应种属:
Human
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宿主来源:
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实验应用:
WB | SDS-PAGE | ATPase Activity Assay | Functional Assay | ELISA
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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免疫原种属:
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克隆性:
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克隆号:
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纯化方式:
Affinity Purified
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偶联:
His tag
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产品浓度:
Lot/batch specific. See included datasheet.
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表达系统:
E. coli
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阳性对照:
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保存温度:
-20ºC
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运输温度:
Blue Ice or 4ºC
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细胞定位:
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预期分子量:
~78 kDa
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产品形式:
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存储溶液:
50mM Tris/HCl, pH 7.5, 150mM NaCl, 10% glycerol
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia (Barnes), to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
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URL:
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灵敏度:
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检测范围:
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检测方法:
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样本类型:
50mM Tris/HCl, pH 7.5, 150mM NaCl, 10% glycerol
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产品特点:
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纯度:
>90%
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生物活性:
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内毒素水平:
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来源:
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表达方式:
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Accession #:
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CAS号:
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分子式:
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溶解度:
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PubChem CID: