Tau Truncated (AA297-391) (dGAE C322A) Pre-formed Fibrils - 深圳欣博盛生物科技有限公司

您现在的位置：首页 > 产品目录 > 产品分类 > 蛋白质，酶与肽 > 重组蛋白 > 其他重组蛋白

Tau Truncated (AA297-391) (dGAE C322A) Pre-formed Fibrils

品牌： Stressmarq

产品货号： SPR-462B

规格： 100 µg

报价：

折后价：

数量： - +

问题咨询

官网链接

说明书

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Tau Truncated (AA297-391) (dGAE C322A) Pre-formed Fibrils
别名:

Tau aggregate, Tau PFFs, Tau PFF, Tau protein aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau protein fragment, Truncated Tau Protein
产品描述:

Human Recombinant Truncated Tau (AA297-391) (dGAE C322A) Protein Pre-formed Fibrils
反应种属:

Human
宿主来源:
实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:

Ion-exchange Purified
偶联:

No tag
产品浓度:

2 mg/ml
表达系统:

E. coli
阳性对照:
保存温度:

-80ºC
运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
细胞定位:
预期分子量:

10.133 kDa
产品形式:
存储溶液:

PBS pH 7.4
有效期:
产地:

加拿大
外观:
生产商:
功能与背景:

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3). The C322A mutation leads to enhanced self-assembly into long and ordered PHFs (3).
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

PBS pH 7.4
产品特点:
纯度:

>95%
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: