Superoxide dismutase Pre-formed Fibrils - 深圳欣博盛生物科技有限公司

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Superoxide dismutase Pre-formed Fibrils

品牌： Stressmarq

产品货号： SPR-470B

规格： 100 µg

报价：

折后价：

数量： - +

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产品名称:

Superoxide dismutase Pre-formed Fibrils
别名:

Superoxide dismutase1 Protein, ALS1 Protein , SOD1 Protein, IPOA Protein
产品描述:

Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
反应种属:

Human
宿主来源:
实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:

Ion-exchange Purified
偶联:

No Tag
产品浓度:

Lot/batch specific. See included datasheet.
表达系统:

E. coli
阳性对照:
保存温度:

-80ºC
运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
细胞定位:
预期分子量:

15.936 kDa
产品形式:
存储溶液:

PB pH 7.4, 5 mM EDTA, 50 mM DTT
有效期:
产地:

加拿大
外观:
生产商:
功能与背景:

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1 (9).
URL:
灵敏度:
检测范围:
检测方法:
样本类型:

PB pH 7.4, 5 mM EDTA, 50 mM DTT
产品特点:
纯度:

>95%
生物活性:
内毒素水平:
来源:
表达方式:
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分子式:
溶解度:
PubChem CID: