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PtdIns-(4,5)-P2 Binding Protein (GST-tagged)
品牌: Cayman
产品货号: 10009815-25 µg
规格: 25 µg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    PtdIns-(4,5)-P2 Binding Protein (GST-tagged)
  • 别名:
    Phosphatidylinositol-4,5-diphosphate|PI(4,5)-P2|PI(4,5)P2 Binding Protein|PIP2|PIP2[4',5'] Binding Protein|PLC-δ1-PH Domain
  • 产品描述:
    Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates.{15263} Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(4,5)-P2 Binding Protein (GST-tagged) contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2 (see Figure 1).{15107} PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096, 8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer{12235} PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    A solution in PBS, pH 7.4, containing 20% glycerol
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  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥90%
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