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Metalloendopeptidase OMA1 (human, recombinant)
品牌： Cayman
产品货号： 28258
规格： 100 µg

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数量： - +
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  • 产品名称:
    Metalloendopeptidase OMA1 (human, recombinant)
  • 别名:
    Metalloprotease-related Protein 1|MPRP-1|OMA1|Overlapping with the m-AAA Protease 1 Homolog
  • 产品描述:
    OMA1 is an ATP-independent metalloproteinase encoded by OMA1.{35969} It is localized to the mitochondrial inner membrane and is comprised of a matrix-facing N-terminal domain, a transmembrane domain, and a C-terminal M48 metallopeptidase domain that is exposed to the intermembrane space.{35969,35970} Under various stress conditions, including oxidative stress, heat stress, and mitochondrial membrane depolarization, OMA1 is activated and cleaves long isoforms of the GTPase optic atrophy 1 (OPA1) at the S1 cleavage site, leading to inhibition of mitochondrial fusion and increased mitochondrial fragmentation.{35969,35970,47769} Under stress conditions, OMA1 is also autocatalytically degraded, thereby limiting, and allowing for reversal of, the stress response.{35970,47769} Oma1-/- mouse embryonic fibroblasts exhibit a loss of mitochondrial fragmentation upon exposure to hydrogen peroxide.{35970} Mice lacking Oma1 exhibit impaired thermogenesis, increased hepatic steatosis and serum triglyceride levels, and high-fat diet-induced obesity.{47770} Cayman’s Metalloendopeptidase OMA1 (human, recombinant) can be used for Western blot and ELISA applications.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris, pH 8.0, with 150 mM sodium chloride, 10% glycerol, 0.5 M L-arginine, and 2 μM zinc chloride
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥90%
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