您好，欢迎光临欣博盛生物科技商城！
服务热线：400 680 0892
购物车图片 购物车 ( )
Hsp90β (human, recombinant)
品牌： Cayman
产品货号： 22735
规格： 50 µg

报价：
折后价：

数量： - +
问题咨询
官网链接
说明书
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
  • 产品名称:
    Hsp90β (human, recombinant)
  • 别名:
    Heat Shock Protein 90β
  • 产品描述:
    Heat shock protein 90 β (Hsp90β) is the constitutively active cytosolic isoform of Hsp90 that is encoded by HSP90AB in humans.{17930} Hsp90 is a multidomain protein that functions as a molecular chaperone to assist in folding and activation of nascent peptides, refolding unfolded or misfolded proteins, and preventing protein aggregation.{15502} C-terminal dimerization of Hsp90, coupled with ATPase molecular clamp activity induces a conformational change in the N-terminal nucleotide binding domain that facilitates substrate binding and initiates the chaperone cycle.{17932} Hsp90 interacts with many co-chaperones during its chaperone cycle including p23 and Sba1, which help recruit substrates to the Hsp90 complex, Hsp70 (Item Nos. 22739 | 23002), which loads nascent polypeptides onto the Hsp90 dimer, and the ATPase activator Aha1 that promotes ATP hydrolysis and substrate release.{17931,41851} Hsp90 is overexpressed in cancer cells and stabilizes client proteins that promote oncogenesis, including transcription factors, signaling proteins, and kinases.{17930,41851} Hsp90 also decreases α-synuclein fibril formation and toxicity as well as Q35 aggregation in in vitro models of Parkinson's and Huntington's disease, respectively, implying a role in neurodegenerative disease.{41852}
  • 反应种属:
  • 宿主来源:
  • 实验应用:
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
  • 纯化方式:
  • 偶联:
  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80
  • 运输温度:
    -80
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
  • 存储溶液:
  • 有效期:
    180
  • 产地:
    美国
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
  • 产品特点:
  • 纯度:
    ≥65% as estimated by SDS-PAGE
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
粤ICP备08007346号
  网站地图
犀牛云提供企业云服务