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cGAS (human, recombinant)
品牌: Cayman
产品货号: 22810
规格: 100 µg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    cGAS (human, recombinant)
  • 别名:
    2’3’-cGAMP Synthase|C6orf150|cGAMP Synthase|Cyclic GMP-AMP Synthase|EC: 2.7.7.86|h-cGAS|Mab-21 domain containing protein 1|MB21D1
  • 产品描述:
    Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response.{22400,22401} Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway.{22400,22401,39161} In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection.{39163} Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses.{39164} In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.{39163}
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM HEPES, pH 8.0, with 300 mM sodium chloride, and 10% glycerol
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  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥90% estimated by SDS-PAGE
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