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SIRT4 (human recombinant)
品牌： Cayman
产品货号： 10317
规格： 100 µg

报价：
折后价：

数量： - +
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  • 产品名称:
    SIRT4 (human recombinant)
  • 别名:
    NAD-dependent ADP-ribosyltransferase Sirtuin 4|Silent Information Regulator 4|SIR2-like Protein 4|SIR2L4|Sirtuin 4
  • 产品描述:
    There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1-SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and ADP-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH).{17731} In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion.{17732} There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized).{17733} SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver. {17732}
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  • 免疫原:
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  • 阳性对照:
  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 存储溶液:
  • 有效期:
    270
  • 产地:
    美国
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  • 纯度:
    ≥95% estimated by SDS-PAGE
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