STING AQ variant (human, recombinant) - 深圳欣博盛生物科技有限公司

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STING AQ variant (human, recombinant)

品牌： Cayman

产品货号： 23592

规格： 100 µg

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数量： - +

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产品名称:

STING AQ variant (human, recombinant)
别名:

Endoplasmic Reticulum Interferon Stimulator|Stimulator of Interferon Genes|TMEM173
产品描述:

STING AQ variant (human recombinant) contains amino acids 138-379 of the wild-type STING variant (R232) with an alanine substituted for glycine at position 230 and a glutamine substituted for arginine at position 293. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers.{24607} Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferons (IFN).{22400,22401,24611} The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 is found at a 13.7% frequency. The G230A, R293Q double mutation occurs in 5.2% of the human population and when expressed in HEK293T cells, this mutation reduces the IFN response to bacterial ligands by 30-40% compared to wild-type STING. Whereas the R293Q substitution alone is severely defective in response to bacterial cyclic dinucleotides, the G230A substitution is thought to help maintain some ability of this variant to respond to bacterial cyclic dinucleotides. Based on crystal structure of STING, the G230A mutation alters the conformation of the lid region that clamps onto the c-di-GMP, however, the R293 residue does not directly bind to c-di-GMP.{38697} The R293Q mutation may instead disrupt STING activity indirectly by altering the function of a nearby cysteine residue required for IFN-β expression.{38698}
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-80
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-80
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50 mM HEPES, pH 8.0, 150 mM sodium chloride, and 10% glycerol
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有效期:

730
产地:

美国
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≥80% estimated by SDS-PAGE
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