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STING R224 variant (human, recombinant)
品牌： Cayman
产品货号： 23593
规格： 100 µg

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折后价：

数量： - +
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  • 产品名称:
    STING R224 variant (human, recombinant)
  • 别名:
    Endoplasmic Reticulum Interferon Stimulator|Stimulator of Interferon Genes|TMEM173
  • 产品描述:
    STING R224 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{22400,22401,24611,24607} The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling.{34537} Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-κB activation.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM HEPES, pH 8.0, with 150 mM sodium chloride, and 10% glycerol
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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  • 纯度:
    ≥70% estimated by SDS-PAGE
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