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TIP60 (human, recombinant)
品牌: Cayman
产品货号: 10783
规格: 100 µg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    TIP60 (human, recombinant)
  • 别名:
    cPLA(2) Interacting Protein|Esa1|Histone acetyltransferase KAT5|HIV-1 Tat Interacting Protein 60 kDa|Hs.6364|HTATIP|KAT5|PLIP
  • 产品描述:
    TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase.{20520} As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription.{20521} In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.{20522}
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris-HCl, pH 7.5, with 300 mM sodium chloride and 10% glycerol
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  • 有效期:
    180
  • 产地:
    美国
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  • 纯度:
    ≥50%
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