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PAD1 (human, recombinant)
品牌： Cayman
产品货号： 10784
规格： 100 µg

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数量： - +
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  • 产品名称:
    PAD1 (human, recombinant)
  • 别名:
    PADI1|PDI1|Peptidylarginine Deiminase 1|Protein Arginine Deiminase 1
  • 产品描述:
    Peptidyl arginine deiminase 1 (PAD1) is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function.{45610,64948} It exists as a monomer and is composed of a C-terminal catalytic domain and two N-terminal immunoglobulin-like (Ig-like) domains.{64948} PAD1 is primarily expressed in uterine and epidermal cells and generally localized in the cytosol.{19490} PAD1 citrullinates non-histone proteins, such as keratin, filaggrin, and MEK1, as well as histone H3 at arginine 2 (H3R2), H3R8, H3R17, and H4R3, to regulate epidermal cell progression and embryonic development.{64949,64950,59195} The catalytic activity of PAD1 is lost by deleting the first six N-terminal amino acids.{64948} Decreased Padi1 expression or PAD1 inhibition reduces citrullination of H3R2, H3R8, H3R17, and H4R3 and inhibits primary mouse embryo preimplantation development.{59145} PADI1 mRNA is overexpressed in tumor tissue from patients with triple-negative breast cancer (TNBC), and PAD1 promotes proliferation and epithelial-to-mesenchymal transition (EMT) in a variety of TNBC cell lines in vitro and in mouse xenograft models.{64951} Cayman's PAD1 (human, recombinant) protein can be used for enzyme activity assay and Western blot (WB) applications.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM HEPES, pH 8.0, with 150 mM sodium chloride, 1 mM DTT, and 20% glycerol
  • 存储溶液:
  • 有效期:
    730
  • 产地:
    美国
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    ≥95% estimated by SDS-PAGE
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