产品描述:
Autophagy-related 5 (ATG5), formerly known as apoptosis specific protein (ASP), is a protein that is essential to autophagosome elongation.{47096,47097,47098} ATG5 is covalently conjugated to the C-terminal glycine residue of ATG12 (ATG12-ATG5) and forms a non-covalent complex with ATG16 (ATG12-ATG5-ATG16), which functions as an E3 ubiquitin ligase-like enzyme to facilitate LC3 transfer from ATG3 to phosphatidylethanolamine in canonical autophagy. ATG12-ATG5 also binds to the ATG12-ATG5-interaction region of the lysosomal localized protein TECPR1, freeing the TECPR1 pleckstrin homology domain to interact with phosphatidylinositol 3-phosphate components in the autophagosome membrane, promoting autophagosome-lysosome fusion.{47098} Polymorphisms in ATG5 have been associated with various autoimmune diseases, including lupus nephritis and Behcet's disease, gastrointestinal and colorectal cancers, as well as sporadic Parkinson's disease and childhood asthma.