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PRMT6 (human recombinant; baculovirus expressed)
品牌: Cayman
产品货号: 13866
规格: 50 µg

报价:
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数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    PRMT6 (human recombinant; baculovirus expressed)
  • 别名:
    Histone Arginine N-methyltransferase PRMT6|HRMT1L6|Protein Arginine Methyltransferase 6
  • 产品描述:
    Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets.{20285,20245,20284} Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6.{20286} H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase.{20287} Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.{20284}
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥60%
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