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Coagulation Factor IX (human, recombinant)
品牌： Cayman
产品货号： 31838-50 µg
规格： 50 µg

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数量： - +
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  • 产品名称:
    Coagulation Factor IX (human, recombinant)
  • 别名:
    Christmas Factor|Coagulation Factor 9|Factor IX|FIX|Plasma Thromboplastin Component|PTC
  • 产品描述:
    Coagulation Factor IX is a vitamin K-dependent plasma serine protease involved in the intrinsic and extrinsic pathways of the blood coagulation cascade.{52852,52855} It is composed of an N-terminal domain containing carboxylated glutamic acid residues (Gla domain), two EGF-like domains, a linker module, and a C-terminal trypsin-like catalytic peptidase domain.{52854} Coagulation Factor IX is produced as an inactive precursor, which is activated to Factor IXaβ following signal peptide cleavage, glycosylation, and further cleavage by Factor XIa or VIIa.{52854} In its activated form, Factor IXaβ, in complex with Factor VIIIa, converts Factor X to Factor Xa, the activated form.{52856} Mutations in F9, the gene encoding Factor IX, are responsible for the X-linked bleeding disorder hemophilia B, characterized by mild to severe deficits in blood coagulation.{52852} Cayman’s Coagulation Factor IX (human, recombinant) protein can be used for enzyme activity applications. This protein consists of 444 amino acids, has a calculated molecular weight of 50 kDa, and a predicted N-terminus of Thr29 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 60-80 kDa due to glycosylation.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 产品形式:
    Lyophilized from sterile PBS, pH 7.4
  • 存储溶液:
  • 有效期:
    365
  • 产地:
    美国
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  • 纯度:
    ≥95% as determined by SDS-PAGE
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